ACESO's Mission
To improve survival for patients with sepsis in austere settings through the development of
Host-Based Diagnostics & Prognostics
Translate systems biology-based host biomarkers to point-of-care diagnostics.
Data-driven Clinical Management
Implement tools and strategies to improve clinical care and outcomes.
The Threat of Sepsis
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection (Singer M et al., 2016). The global estimate of sepsis is 30 million episodes and 6 million deaths per year, however this is likely an underestimate due to the lack of reliable data from Resource Limited countries where 87% of the world population lives (Fleischmann C et al., 2016). In May 2017, the World Health Organization (WHO) adopted a resolution aimed to improve the prevention, diagnosis and management of sepsis illustrating the urgency of the problem (Reinhart K et al., 2017).
The Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO) was established in 2010 by Dr. Danielle Clark, former HJF scientist in support of HJF-ACESO and Dr. James Lawler, Director, Clinical Research Department, Biological Defense Research Directorate (BDRD) Naval Medical Research Command (NMRC) as a consortium of government, non-profit, academic, and industry partners to develop clinical management solutions for infectious diseases in resource-limited setting globally and improve survival for patients with sepsis.
Biomarkers
HJF-ACESO is exploring host-based biomarkers for early recognition and individualized management of sepsis analyzing various biological signatures to increase understanding of the pathogenesis and related host response pathways associated with common and/or dangerous infectious agents.
Clinical Practice
HJF-ACESO seeks to improve clinical practices by developing evidence-based guidelines for management of clinical syndromes in patients with severe infections through clinical trials across the globe.
Prediction
ACESO seeks to collaborate with global developers to implement point-of-care analytics to predict the best clinical course to improve patient outcome.
What is ACESO Doing?
By facilitating and coordinating a research network of military and academic partners, HJF-ACESO aims to improve early recognition, diagnosis, and treatment of this deadly disease.
Number of Sites
Clinical Protocols
Enrollment in Last 90 Days (A/O 26Aug2024)
Total Enrollment