ACESO's Mission
To improve survival for patients with sepsis in austere settings through the development of
Host-Based Diagnostics & Prognostics
Translate systems biology-based host biomarkers to point-of-care diagnostics.
Data-driven Clinical Management
Implement tools and strategies to improve clinical care and outcomes.
The Threat of Sepsis
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection (Singer M et al., 2016). The global estimate of sepsis is 30 million episodes and 6 million deaths per year, however this is likely an underestimate due to the lack of reliable data from Resource Limited countries where 87% of the world population lives (Fleischmann C et al., 2016). In May 2017, the World Health Organization (WHO) adopted a resolution aimed to improve the prevention, diagnosis and management of sepsis illustrating the urgency of the problem (Reinhart K et al., 2017).
The Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO) was established in 2010 by Dr. Danielle Clark, former HJF scientist in support of ACESO and Dr. James Lawler, Director, Clinical Research Department, Biological Defense Research Directorate (BDRD) Naval Medical Research Command (NMRC) as a consortium of government, non-profit, academic, and industry partners to develop clinical management solutions for infectious diseases in resource-limited setting globally and improve survival for patients with sepsis.
Biomarkers
ACESO is exploring host-based biomarkers for early recognition and individualized management of sepsis analyzing various biological signatures to increase understanding of the pathogenesis and related host response pathways associated with common and/or dangerous infectious agents.
Clinical Practice
ACESO seeks to improve clinical practices by developing evidence-based guidelines for management of clinical syndromes in patients with severe infections through clinical trials across the globe.
Prediction
ACESO seeks to collaborate with global developers to implement point-of-care analytics to predict the best clinical course to improve patient outcome.
What is ACESO Doing?
By facilitating and coordinating a research network of military and academic partners, ACESO aims to improve early recognition, diagnosis, and treatment of this deadly disease.
Number of Sites
Clinical Protocols
Enrollment in Last 90 Days (A/O 26Aug2024)
Total Enrollment